Niels C. Pedersen, DVM PhD We had hoped that in 2023 one or more antivirals for cats would be legalized. With the exception of a few countries outside the US, this has not happened. Still, there is hope that studies being conducted at the University of California, Davis and elsewhere Read more…
Niels C. Pedersen, DVM PhD Distinguished Professor Emeritus UC Davis, Center for Companion Animal Health Updated February 10, 2023 Background What is FIP? – FIP is caused by a common and a largely innocuous enteric coronavirus, like those causing colds in humans and diarrhea in foals, calves, and poultry. Most cats Read more…
Niels C. Pedersen, DVM PhDApril 1, 2023 It is important in discussing feline coronavirus (FCoV) infection in multi-cat environments to understand correct nomenclature. The term FCoV is a collective term for two historically named viruses. A coronavirus was ultimately identified as the cause of feline infectious peritonitis (FIP) in cats Read more…
Niels C. Pedersen, DVM PhDNovember 28, 2022 I am pleased to inform you that I have left my advisory role with SOCKFIP and now officially joined the SOCKFIP board. This reflects my transition from university to private life but will not affect my dedication to FIP research. Hopefully, this more Read more…
Niels C. Pedersen, DVM, PhDCenter for Companion Animal HealthUniversity of California, DavisJune 14, 2022 Origin of FIP effusions. Effusions of wet FIP originate from small, inflamed blood vessels (venules) within the tissue that lines the surfaces of abdominal and thoracic organs,mesenteries/mediastinum, and omentum. This thin tissue or membrane is called Read more…
Niels C. Pedersen DVM, PhD October 20, 2021 Beta-d-N4-hydroxycytidine is a small molecule (nucleoside) that was studied in the late 1970s in the old Soviet Union as part of biological weapons research [2]. Weaponization of diseases like smallpox was a worldwide fear, but the dangers of using smallpox virus for this Read more…
NC. Pedersen, DVM PhD March 23, 2022 Several questions frequently arise during FIP treatment. Before discussing these questions, it is important to review the status of FIP treatment. Only antiviral drugs that target specific viral proteins and inhibit replication of FIP virus have been shown to be curative. At present, Read more…
Niels C. Pedersen, Nicole Jacque November 3, 2021 Introduction Resistance to antiviral diseases has been well documented for diseases like HIV/AIDs and hepatitis C. In some cases, this resistance is present in the infecting virus, but more frequently it is a result of prolonged drug exposure. Resistance to both GC376 Read more…
Niels C. Pedersen, DVM PhD, Distinguished Professor Emeritus Center for Companion Animal Health School of Veterinary Medicine, UC Davis We use the same criteria for monitoring treatment as described in the JFMS field trial paper. Owners are asked to keep track of temperature, weight, activity, appetite, clinical signs of original Read more…
Background– Feline leukemia virus (FeLV) is a retrovirus related to murine leukemia virus that has existed among feral cats for tens of thousands of years before its discovery in 1964 (Jarrett, et al., 1964). FeLV infection occurs mainly among cats under 3-8 years of age (reviewed Pedersen, 1998, 1991). The Read more…